Ghostbusters: The Video Game was penned by original Ghostbusters writers Harold Ramis and Dan Aykroyd and reunites members of the original cast for the first time in 20 years. Bill Murray, Dan Aykroyd, Harold Ramis, and Ernie Hudson lend their voices and in-game likenesses to the original story set two years after Ghostbusters II, with Manhattan once again overrun by ghosts and supernatural forces. The team work as ghost hunters for hire, cleaning up Manhattan's buildings of slime-spewing spooks. The game also features performances from fan favourites such as William Atherton (Walter Peck), Annie Potts (Janine Melnitz) and Brian Doyle-Murray (portraying Mayor Jock Mulligan).

2009 also marks the 25th Anniversary of the original theatrical release of Ghostbusters. The film spawned some of the most memorable comedic catch-phrases and scenes in motion picture history. When Manhattan is once again overrun by ghosts and other supernatural creatures, players will take on the role of a new recruit joining the famous Ghostbusters team.